Nov 19, 2025
These results have several important implications for how we support children who are neurodiverse — whether they carry diagnoses of ASD, ADHD, or both.
A new study from the Child Mind Institute reveals that traits of autism (rather than strict diagnostic labels) align with measurable brain connectivity patterns and gene-expression signatures across both Autism Spectrum Disorder (ASD) and Attention‑Deficit/Hyperactivity Disorder (ADHD).
Key findings:
Researchers studied 166 verbally-able children aged 6–12 (63 with ASD diagnosis, 103 with ADHD).
They found that higher severity of autistic traits in any child (regardless of whether the child had an ASD or ADHD diagnosis) corresponded with increased connectivity between the brain’s frontoparietal/executive-control network and the default-mode network (DMN).
The same children showed reduced segregation between the DMN and attention/visual-processing networks — contrary to typical brain development where these networks become more distinct with age.
When mapping brain connectivity to gene-expression data, genes associated with neural growth and projection (previously implicated in both ASD and ADHD) were over-represented.
Importantly, no specific connectivity pattern corresponded to ADHD symptoms alone — suggesting autistic traits may drive the shared biological signal.
The authors propose a dimensional model of neurodevelopmental differences (focusing on trait severity) rather than strictly categorical diagnoses.
Practical Meaning for Educators, Parents & Caregivers
These results have several important implications for how we support children who are neurodiverse — whether they carry diagnoses of ASD, ADHD, or both.
1. Focus on Traits, Not Just Labels
Rather than thinking solely in terms of “autism = this” and “ADHD = that”, this research encourages us to look at the presence and severity of traits (social-communication differences, attention/impulsivity, executive-control challenges) across children. Educators and parents can benefit by monitoring and supporting these underlying features, regardless of formal diagnosis.
2. Tailor Support Based on Brain-Network Insights
The finding that stronger autistic traits are linked to greater connectivity between executive-control and default-mode networks suggests a brain that may be processing self-referential thinking, internal distraction or mind-wandering more strongly. For children with these profiles, practical strategies might include:
Structured “focus/time-out” zones to modulate internal rumination and help shift between thought modes.
Visual cueing or transitions that help move from self-reflection (DMN) to task-oriented activity (executive-control network).
Activities that scaffold attention control and switching between internal and external focus (e.g., guided breathing, mindfulness, alternating movements and tasks).
3. Environments Matter & Sensory Design Helps
Since connectivity patterns reflect how brain networks switch and integrate information, supporting children means designing environments that minimize distractions and help them regulate shifts in attention and self-focus. For example:
Dedicated quiet corners or “brain reset” spaces (read “Burble Spaces”) in classrooms or homes where children can recalibrate.
Sensory-calming tools (soft textures, gentle lighting, minimal visual clutter) to reduce internal noise and allow better network transitions.
Movement breaks or guided transitions between activities to engage varied brain networks and help shift from internal to external focus.
4. Implications for Research & Early Intervention
For researchers and clinical practitioners working in neurodiversity, the dimensional-trait approach supports early screening and intervention based on trait severity rather than waiting for full diagnostic criteria. This may open pathways for more personalized support plans:
Tracking social communication or executive control traits over time.
Using brain-connectivity or gene-expression insights (in research contexts) to refine sub-group interventions.
Collaborating with educators and caregivers on environmental/behavioral modifications that align with brain-network profiles.
Connection to Sensory-Based Learning & Imagination
At Burble Creativity, we believe that sensory-based learning environments and imaginative play are vital tools for supporting brain development in neurodiverse children. This new research highlights how internal brain-network dynamics (executive vs. default mode) matter — and our sensory-rich, flexible spaces can help bridge those internal states.
For example:
Creative “Story Tents” or sensory nooks provide a safe, soft-edged space where children can shift from internal reflection (possibly overactive DMN) into imaginative, external interaction (activating controlled networks).
Multi-sensory prompts (textures, light changes, movement, storytelling) help engage brain networks in transitions — fostering stronger connectivity and healthier network segregation.
Imaginative play grounds internal thoughts into external expression: children explore ideas, move their bodies, engage space and story, helping them switch from self-referential thinking to external modulation.
By aligning sensory design, imaginative learning, and an understanding of brain-network dynamics, we create conditions that support connection, focus, and flourishing for neurodiverse learners.
Key Takeaway
When we shift from labels to traits — and from fixed diagnoses to flowing brain-network dynamics — we open up richer, more inclusive ways to support neurodiverse children. And by designing learning spaces and experiences that respond to those unique brain patterns (through sensory design and imaginative play), we can help minds not just adapt — but thrive.
