A new study from Daegu Gyeongbuk Institute of Science and Technology (DGIST) — led by Professors Eom Ji-won and Ko Jae-won — may help explain why many autistic people struggle with communication. The researchers identified a molecular abnormality: a mutation in the protein collybistin (encoded by the gene ARHGEF9). This mutation weakens inhibitory synaptic function in the brain by disrupting the normal activity of another protein, gephyrin, which stabilizes the “braking” signals neurons use to modulate activity. 

When this inhibitory signaling falters, the balance between excitatory (accelerating) and inhibitory (braking) signals in the brain becomes distorted — making neuronal communication less stable and reliable. The DGIST team demonstrated this by removing the collybistin gene in the prefrontal cortex of mice. While excitatory synapses remained largely normal, inhibitory synapse density and function declined. 

Strikingly, these “collybistin-deficient” mice showed marked reductions in their ultrasonic vocalizations — a core mouse communication behavior — even though other behavioral measures looked normal. This parallels human reports of both verbal and nonverbal communication difficulties among some autistic individuals. 

Because inhibitory circuits play a central role in regulating neural signaling, this molecular-level disruption could be a foundational cause of the social-communication challenges seen in autism. The authors of the study suggest that their findings may open pathways toward targeted therapies for social communication deficits in autism and related conditions. ,

• Communication delays or difficulties may stem from brain wiring — not willful “deficits.” This study reinforces that communication challenges in autism don’t always arise because someone doesn’t want to connect — sometimes the brain’s internal “wiring” makes communication harder.

• Support needs to be realistic and brain-informed. Traditional therapies focused only on social skills or behavioral training might miss underlying neurobiological differences. Recognizing that inhibitory synaptic dysfunction can underlie communication struggles encourages approaches that are patient, flexible, and neurobiology-aware.

• Hope for future treatments — but with caution. The DGIST findings point toward potential molecular-targeted interventions. However, translating from mice (or molecular models) to human therapies is a long process. For now, the practical takeaway is acceptance, accommodation, and supportive environments.

• Reinforce neurodiversity-friendly, inclusive education and care. When we understand that communication differences may root in brain biology, we strengthen the case for accepting diverse communication styles — not “fixing” them. For educators and caregivers, this means providing space for alternate communication methods, extra processing time, and validating different ways of expressing thoughts or feelings.

Connecting to Sensory-Based Learning & Imagination (Why This Matters for Us at Burble Creativity)

At Burble Creativity, we’re advocates for sensory-based learning, neurodiversity, and imaginative environments — especially for neurodivergent learners. The DGIST findings give powerful biological backing to why sensory-rich, flexible, and inclusive learning spaces are so essential: because autistic learners may communicate differently, not “improperly.”

When educators and caregivers design learning environments that accommodate different neural wiring — offering multimodal communication (visual, tactile, written), sensory supports, and patient pacing — they align with the brain’s realities. These settings don’t “force” neurodivergent children to adapt to neurotypical norms; they honor neurodiversity and allow imagination and self-expression to flourish.

Moreover, in an environment that respects neural difference, autistic learners may feel safer to explore creativity, sensory experiences, and expressive play — without the pressure or stigma attached to “fixing” what isn’t broken. That’s the core of what Burble Creativity stands for: inclusive imagination, not conformity.

Burble Creativity is a technology company that creates immersive storytelling environments that spark imagination and support